PGT-M
Preimplantation Genetic Testing
For Monogenic Diseases
What is PGT – M
PGT – M enables couples with an inheritable genetic condition in their family to avoid passing it on to their children. It is a powerful test performed prior to implantation to help identify single gene defects within embryos created through IVF to avoid conceiving a child with a genetic disorder.
Preparation or a set up test may be necessary prior to starting a PGT – M cycle. Most of the time, blood samples from the couple are required and all tests must be scheduled in advance and coordinated through Cytogenomix Services Team.
INDICATIONS FOR PGT-M
Your physician may recommend PGT – M if :
- You have previous pregnancy termination(s) because of a serious genetic condition
- You already have a child with a serious genetic condition
- You have a family history of a serious genetic condition, or
- You have a family history of chromosome problems.
Examples of some common single gene disorders
| Alpha thalassemia | Hemophilia A & B |
| Beta thalassemia | Duchene muscular dystrophy |
| Cystic fibrosis | Becker’s muscular dystrophy |
| Spinal muscular atrophy | Glucose – 6 – phosphate dehygenase deficiency |
