Infertility Genetics | Reprogene HIM & HER Panels

Understanding the Genetic Basis of Infertility

Infertility affects approximately 15% of couples worldwide, with genetic factors contributing to up to 50% of cases. Our comprehensive Reprogene panels provide crucial insights into the genetic causes of infertility, enabling personalized treatment strategies and improving IVF success rates.

Sample Requirements: 3-5 mL whole blood (EDTA) and 3-5 mL Sodium heparin tube (Green Cap)

15%

Couples Affected

50%

Genetic Factors

235+

Genes Analyzed

Whether you're planning IVF, experiencing recurrent pregnancy loss, or seeking answers about fertility challenges, our genetic testing panels provide the answers you need for informed decision-making.

Explore Testing Panels

Our Infertility Genetic Testing Panels

Comprehensive, clinically-relevant genetic analysis for both partners

Reprogene HIM

Male Infertility Panel

139 Genes Analyzed

Constitutional Karyotyping Detection of chromosomal abnormalities

Y-chromosome Microdeletion AZF region analysis (AZFa, AZFb, AZFc)

NGS Panel - 139 Genes Comprehensive analysis of male infertility genes

Key Genes Analyzed:

ACTL9

ADGRG2

AIRE

AKR1C4

AMH

AMHR2

ANOS1

AR

ARL6

ARMC2

ARX

ATRX

AURKC

AXL

BBS1

BBS10

BBS12

BBS2

BBS4

BBS5

BBS7

BBS9

BRDT

C14orf39

CATSPER1

CBX2

CCDC141

CEP112

CFAP251

CFAP43

CFAP44

CFAP47

CFAP58

CFAP65

CFAP69

CFAP70

CFAP91

CFTR

CHD7

CYP11A1

CYP17A1

CYP19A1

DHH

DMRT1

DMRT2

DNAH1

DNAH10

DNAH17

DNAH2

DNAH6

DNAH8

DPY19L2

DUSP6

DZIP1

FANCM

FEZF1

FGF17

FGF8

FGFR1

FGFR2

FLRT3

FOXL2

FSHB

FSIP2

GALNTL5

GATA4

GNRH1

GNRHR

HESX1

HFE

HS6ST1

HSD17B3

IL17RD

INSL3

KISS1

KISS1R

KLHL10

LEP

LEPR

LHB

LHCGR

LHX3

LHX4

M1AP

MAMLD1

MAP3K1

MKKS

NANOS1

NPAS2

NR0B1

NR5A1

NSMF

PCSK1

PICK1

PLCZ1

PMFBP1

PNLDC1

POR

PPP2R3C

PROK2

PROKR2

PROP1

QRICH2

RSPO1

SEMA3A

SEMA3E

SEPTIN12

SLC26A8

SOHLH1

SOX10

SOX2

SOX3

SOX9

SPATA16

SPEF2

SPRY4

SRA1

SRD5A2

SRY

STAR

SUN5

SYCE1

SYCP2

SYCP3

TAC3

TACR3

TAF4B

TEX11

TEX14

TEX15

TRIM32

TTC21A

TTC29

TTC8

WDR11

WNT4

WT1

WWOX

ZMYND15

Comprehensive panel covering spermatogenesis, hormonal regulation, and structural sperm defects

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Reprogene HER

Female Infertility Panel

96 Genes Analyzed

Constitutional Karyotyping Detection of chromosomal abnormalities

FMR1 CGG Trinucleotide Repeat Fragile X syndrome & POI risk assessment

NGS Panel - 96 Genes Comprehensive analysis of female infertility genes

Key Genes Analyzed:

ACE

AMOT

BMP15

CAPN10

CBS

CPB2

CYP11A1

CYP17A1

CYP19A1

CYP21A2

DENND1A

EIF2B2

EIF2B3

EIF4E

F10

F11

F12

F13A1

F13B

F2

F2R

F3

F5

F7

F8

F9

FGA

FGB

FIGLA

FMR1

FOXL2

FSHB

FSHR

GALT

GDF9

GNAS

GNRH1

GNRHR

GP1BA

GP1BB

GP5

GP9

INS

INSR

IRS1

IRS2

ITGA2

ITGB3

KHDC3L

KISS1

KISS1R

KLF4

KLKB1

LHB

LHCGR

MTHFR

MTR

MTRR

NANOG

NOBOX

NOC4L

NOP2

NR5A1

PADI6

PLAT

PLAUR

PLG

PLK4

POF1B

POLG

PROC

PROCR

PROS1

PSMC3IP

SALL4

SERPINC1

SERPINE1

SERPINF1

SETD1A

SMCHD1

SOX2

STAG3

TACR3

TEAD4

TFPI

THADA

THBD

TLE6

TUBB8

WT1

ZAR1L

ZC3H4

ZP1

ZP2

ZP3

ZP4

Comprehensive panel covering ovarian function, coagulation disorders, and recurrent pregnancy loss

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Panel Comparison

Understanding the scope of each test

Feature	Reprogene HIM	Reprogene HER
Constitutional Karyotyping	Included	Included
Y-chromosome Microdeletion	AZFa, AZFb, AZFc	Not applicable
FMR1 CGG Repeat Analysis	Not applicable	Included
NGS Panel Size	139 genes	96 genes
Turnaround Time	21-28 days	21-28 days
Sample Requirements	3-5 mL EDTA + Sodium heparin	3-5 mL EDTA + Sodium heparin

When to consider Reprogene HIM

Azoospermia or severe oligospermia
Recurrent IVF/ICSI failure
Non-obstructive azoospermia
Cryptorchidism or hypogonadism
Family history of male infertility
Abnormal hormone levels (FSH, LH, testosterone)

When to consider Reprogene HER

Recurrent pregnancy loss (≥2 miscarriages)
Premature ovarian insufficiency (POI)
Unexplained infertility
Polycystic ovary syndrome (PCOS)
Family history of Fragile X syndrome
Implantation failure after IVF

Frequently Asked Questions

Common questions about infertility genetic testing

Should both partners be tested?

Yes, we recommend testing both partners simultaneously as infertility can have genetic causes in either partner. Testing both provides a complete picture and helps guide treatment decisions, especially for IVF/ICSI planning.

How long does it take to get results?

Results are typically available within 21-28 days from sample receipt. Karyotyping results may be available earlier, while the comprehensive NGS analysis requires additional time for bioinformatics processing and variant interpretation.

Will genetic counseling be provided?

Yes, all patients receiving infertility genetic testing are offered pre- and post-test genetic counseling with our certified genetic counselors to help interpret results and discuss implications for family planning.

Can these tests be done during IVF treatment?

Yes, we recommend testing before starting an IVF cycle to allow time for results to inform treatment decisions. However, testing can be done at any point and results used for future cycles.

What is the success rate of finding a genetic cause?

The diagnostic yield varies by indication but ranges from 15-30% depending on the specific phenotype. Our comprehensive panels maximize the chance of identifying clinically relevant genetic variants.

What are the sample requirements?

Both panels require 3-5 mL whole blood in an EDTA tube (purple cap) and 3-5 mL whole blood in a Sodium heparin tube (green cap). Samples should be shipped at room temperature and arrive at the laboratory within 48 hours of collection.

Ready to order infertility genetic testing?

Our genetic counselors and client services team are ready to assist with test selection, sample collection, and result interpretation.

Ordering Information Speak with a Genetic Counselor

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