Oncogenetics | Hereditary Cancer Testing | Cytogenomix® Malaysia
Hereditary Cancer Risk Assessment

Oncogenetics

Comprehensive genetic testing for hereditary cancer syndromes. Identify inherited risks, guide screening, and enable personalized prevention strategies.

6+ CANCER PANELS
6+ GENES ANALYZED
5-10% OF CANCERS ARE HEREDITARY
2-3 WEEKS TAT

Understanding Hereditary Cancer

Approximately 5-10% of all cancers are hereditary, caused by inherited genetic mutations that significantly increase lifetime cancer risk. Identifying these mutations through genetic testing enables:

  • Risk Assessment: Quantify lifetime cancer risk for individuals and families
  • Enhanced Screening: Earlier and more frequent surveillance for at-risk individuals
  • Prevention Strategies: Risk-reducing medications or surgeries
  • Family Planning: Options for at-risk family members
  • Treatment Guidance: Targeted therapies based on genetic profile

Our oncogenetics testing panels are designed to identify clinically actionable mutations in genes associated with breast, ovarian, colorectal, uterine, pancreatic, prostate, and other hereditary cancers.

Genetic Counseling for Cancer Risk

Key Hereditary Cancer Syndromes

Common inherited cancer conditions we test for

HBOC Syndrome

Hereditary Breast & Ovarian Cancer
BRCA1 BRCA2 PALB2 ATM CHEK2

Associated Cancers:

  • Breast (up to 72% risk)
  • Ovarian (up to 44% risk)
  • Pancreatic
  • Prostate (in men)
  • Melanoma
Lifetime Risk: Up to 72%

Lynch Syndrome

Hereditary Non-Polyposis Colorectal Cancer (HNPCC)
MLH1 MSH2 MSH6 PMS2 EPCAM

Associated Cancers:

  • Colorectal (up to 80% risk)
  • Endometrial (up to 60% risk)
  • Ovarian
  • Gastric
  • Small bowel
Lifetime Risk: Up to 80%

Familial Adenomatous Polyposis

FAP
APC

Associated Cancers:

  • Colorectal (100% risk without colectomy)
  • Duodenal
  • Thyroid
  • Gastric
Lifetime Risk: 100%

Li-Fraumeni Syndrome

LFS
TP53

Associated Cancers:

  • Breast
  • Sarcomas
  • Brain tumors
  • Adrenocortical carcinoma
  • Leukemia
Lifetime Risk: >90%

Hereditary Cancer Panels

Comprehensive testing options for different clinical scenarios

Breast & Ovarian Cancer Panel

14 genes

BRCA1, BRCA2, PALB2, ATM, CHEK2, TP53, PTEN, CDH1, STK11, BARD1, BRIP1, RAD51C, RAD51D, NBN

Colorectal Cancer Panel

16 genes

MLH1, MSH2, MSH6, PMS2, EPCAM, APC, MUTYH, PTEN, STK11, SMAD4, BMPR1A, GREM1, POLE, POLD1, AXIN2, NTHL1

Pan-Cancer Panel

47 genes

Comprehensive panel covering all major hereditary cancer syndromes including breast, ovarian, colorectal, uterine, pancreatic, prostate, melanoma, and more.

Pancreatic Cancer Panel

12 genes

BRCA1, BRCA2, PALB2, ATM, CDKN2A, STK11, PRSS1, SPINK1, CFTR, MEN1, VHL, TP53

Prostate Cancer Panel

14 genes

BRCA1, BRCA2, ATM, CHEK2, HOXB13, MLH1, MSH2, MSH6, PMS2, EPCAM, NBN, PALB2, RAD51D, TP53

Endometrial Cancer Panel

10 genes

MLH1, MSH2, MSH6, PMS2, EPCAM, PTEN, STK11, TP53, POLD1, POLE

Featured Oncogenetics Tests

Commonly ordered hereditary cancer panels

BRAFV6

BRAF V600 Mutation

10 days Bone Marrow, Peripheral Blood
Details
BRCAML

BRCA1 AND BRCA2 Rearrangement

3 ml peripheral blood in EDTA (purple/pink top) tube
Details
PNL029

Breast-ovarian cancer, essential (2 Genes)

3 ml peripheral blood in EDTA (purple/pink top) tube
Details
CALRES

CALR Exon 9 (Sequencing)

10 Days 1x EDTA (Lavender) dedicated to Genetics (only one tube needed for JAK2/CALR/MPL testing)
Details
PNL282

Herediatry Cancer Multigene Panel Test (174 Genes)

3 weeks 3 ml peripheral blood in EDTA (purple/pink top) tube
Details
HERCA1

Herediatry Cancer Multigene Panel Test (81 Genes)

Blood in EDTA
Details
PNL028

Hereditary Breast-Ovarian/Gynaecologic Cancer Panel (31 Genes)

3 ml peripheral blood in EDTA (purple/pink top) tube
Details
PNL131

Hereditary cancer (all genes) (91 Genes)

3 weeks 3 ml peripheral blood in EDTA (purple/pink top) tube
Details
View All Oncogenetics Tests

Who Should Consider Hereditary Cancer Testing?

NCCN guidelines recommend testing for individuals with the following criteria

Personal History

  • Diagnosed at age ≤50
  • Multiple primary cancers
  • Rare cancer types
  • Triple-negative breast cancer
  • Metastatic prostate cancer
  • Pancreatic cancer at any age

Family History

  • Known familial mutation
  • Multiple affected relatives
  • Early-onset cancers in family
  • Male breast cancer
  • Ashkenazi Jewish ancestry
  • Clustering of related cancers

Tumor Features

  • Mismatch repair deficiency
  • Microsatellite instability
  • High tumor mutational burden
  • Specific immunohistochemistry results

Risk Management Options

Personalized strategies based on genetic findings

Enhanced Screening

Earlier and more frequent mammograms, MRI, colonoscopy

Chemoprevention

Risk-reducing medications like tamoxifen or aspirin

Risk-Reducing Surgery

Prophylactic mastectomy or salpingo-oophorectomy

Cascade Testing

Testing at-risk family members

Targeted Therapy

PARP inhibitors for BRCA carriers

Lifestyle Modifications

Personalized prevention strategies

Family Planning

PGT for hereditary cancer syndromes

Genetic Counseling

Ongoing support and guidance

Genetic Counseling is Essential

All oncogenetic testing includes pre- and post-test genetic counseling with our board-certified genetic counselors. We help you understand your results, implications for family members, and guide you through risk management options.

Pre-test counseling
Informed consent
Result interpretation
Family implications
Management guidance

Frequently Asked Questions

Common questions about hereditary cancer testing

What is the difference between germline and somatic testing?

Germline testing (what we offer) looks for inherited mutations present in all cells of the body. Somatic testing looks for mutations within tumor tissue only. Germline results have implications for family members and lifelong risk management.

How long does it take to get results?

Most hereditary cancer panels have a turnaround time of 2-3 weeks from sample receipt. Rush options may be available for urgent clinical situations.

What happens if a mutation is found?

Our genetic counselors will discuss the implications, recommend enhanced screening and prevention strategies, and facilitate testing for at-risk family members (cascade testing).

Will insurance cover genetic testing?

Many insurance plans cover hereditary cancer testing for individuals meeting clinical criteria. Our team can assist with pre-authorization and insurance verification.

What sample is required?

3-5 mL whole blood in EDTA tube (purple top). Saliva kits are also available for patients who cannot provide blood.

What is a VUS (Variant of Uncertain Significance)?

A VUS is a genetic change whose impact on cancer risk is unknown. Our laboratory monitors new evidence and may reclassify VUS over time. Genetic counseling helps interpret these results.

Ready to Learn About Your Cancer Risk?

Our genetic counselors and oncogenetics specialists are ready to help you understand your hereditary cancer risk.

Schedule a Consultation Browse Cancer Panels

Or call us: +603-1234-5678