Test Code: BONKAR
Bone Marrow Karyotyping
Oncogenetics
Chromosome analysis of bone marrow is a key tool for assessing remission or relapse of malignancy and identifying abnormal clones, with a normal karyotype in conditions such as myelodysplastic syndrome, acute myeloid leukemia, acute lymphoblastic leukemia, or lymphoproliferative disorders generally serving as a favorable prognostic indicator; follow-up specimens may be submitted to monitor karyotypic evolution as the clinical course changes, and bone marrow is the preferred sample type over peripheral blood, with a minimum of 20 cells analyzed, while stimulated and unstimulated blood cultures are established only if peripheral blood is received alongside bone marrow, and stimulated blood cultures are examined only if bone marrow cultures fail, with GTW banding performed on metaphase spreads.
Sample Type
Bone marrow volume depends on sample availability and calculated white cell count, and specimens may be submitted using heparinized syringes or sodium heparin vacutainers.
Turnaround Time
2 weeks days
Courier Requirements
Ship overnight at room temperature to receive next day. Do not refrigerate or freeze. Maintain specimen at room temperature.
Pricing
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Genes Analyzed
1 genes
NA
Methodology
GTW banding is performed on metaphase spreads
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